I don't use gloves but I have a few in my diaper change area that I can use if I have to put cream on what I believe to be a suspect rash. For just regular changes and diaper cream I dont' wear one. I have used a wad of toilet paper to spread the ceam in a pinch which I also keep a roll of in the diaper change area for wiping noses etc. while I have a captive child laying down.