I live by the philosophy that not everything has to be clean at the same time. By this I mean bathrooms are Sunday, floors are Monday, Vacuuming is Tuesday etc.. If it's needed inbetween I do it (bathrooms get a daily wipe down with a lysol cloth), but generally I stick to a chores particular day. That way my house is always passably clean and I am never overwhelmed. As for picking up I do it throughout the day and one final walk through before bed with the hubbs.