The fact he isn't normally on a puffer at your house and assuming he uses two - the slower 2x a day one and then the emergency puffer which is used more often as needed - so assuming that is the one you are using now. If he is not getting any relief and has tried it at least a couple times - as in at home and again mid morning and now again at nap with no change then he is in need of the meds a different way and may very well need to be in hospital with a mask treatment. And yes if they are all sick then he probably has an underlying illness that is setting the asthma off which makes it more serious.
Mom needs to be told to come and take him to the doctor or better yet the children's hospital and they will put a mask on him anyways till they assess him and that might be just enough to take the edge off. The doctor will likely just send him home to keep uselesslly puffing.
If you do keep him be prepared to call 911 if he shows the slightest amount of not being able to breathe in totally. But at least give mom a heads up of the state he is in and what your option will be - at her expense if she doesn't come and get him. I would be letting him sit up on the couch for nap rather than laying down too.

































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