I do a full disinfect (all toys, blocks, puzzles, wipe down all furniture and large articles) every week. That's what the daycare centres I worked in did, so I've followed suit. My kids last year were mostly big, so I did it once per month and that seemed ok. With the little guys I have now (all under 2) I found it just wasn't enough. They put everything in their mouths and were constantly battling something...drove me nuts! I've noticed a huge difference in the number of bugs floating through here. I can't believe there's been nothing in over a month....not even a runny nose! Even I haven't had a cold as yet, which is unheard of for me. I don't get sick often, but usually can't avoid the colds. It takes a bit of effort to incorporate it in my weekly routine, but now I'm used to the extra work....and not being sick or losing money