The biggest thing for me is I made a decision on the ages I would care for. I don't do the school runs to the bus so only care for children 3 and under. That means toys and supplies such as scissors, markers, small lego, etc. is not available to the children. In a daycare centre where there are separate rooms for age groups these items would be out for 3 year olds and above. What you need to do is childproof the room for the babies and have the things you need for the older kids up on high shelves or in locked cupboards that you can bring out for supervised use. Make sure you have a play yard or area of your room sectioned off for the babies that you can be sure has only baby safe items in it and is used only with the babies. Then if you want to do a craft with the older ones or need to run to the bathroom you have a place to put them.