It's funny but I was just having this talk with someone. I have two 1 year old children in care, a 2 year old and a 3 year old. The age range isn't a problem because the two little ones ride in the stroller and the older ones walk everywhere.
They all eat the same food, sleep the same hours, the only difference is that I change the babies diapers and put the older ones on the potty. The older ones are able to colour, play with playdo and craft more independently while the babies need more hands on help, but otherwise everything flows well throughout the day. I don't think you will have any problem.