Her problem is more likely to be boredom than anything else. Be very careful that you aren't giving too much of yourself during the week. If you are always available to play with her, make a puzzle, play a game, sing a song, give a hug, etc. she won't understand why you have to dust and scrub and do laundry on the weekend instead of entertaining her. I had that complaint in my first years as a provider from a single parent. It was after that that I instituted the free play is just that meaning I am free to do what I want (need to do) and not there to cater to their every whim. They play with what is available that day and come to me for help only after they have tried.

If you have a separate space it also means everything that is familiar to her is off limits so to speak - she can't be down in the basement alone while you are upstairs dusting bedrooms or whatever. Evenings aren't an issue because there is so little time once kids go home, supper, then bed with only minimal playtime.

What about taking her down on Fridays after daycare and helping her pack up a laundry basket of things toys to bring upstairs for the weekend and then on Sunday take them back down. That way at least she has something familiar to play with. Kids get attached to particular dolls, blankets, balls, etc. For all intents and purposes it is like she is a guest in someone else's house. Gotta look at it from her perspective.

While my special needs child doesn't really play with the daycare kids they entertain her just from being there and doing stuff for her to watch. On weekends she wanders around and of course she finds things to do like open a drawer, or take all the magazines off a shelf, or toss all the nap blankets on the floor.