I have contact dermatitis and am sensitive to even hypoallergenic things. I tried everything when I was younger and now when it gets really bad I just use Vaseline but even the petroleum in that can irritate me if my hands are inflamed and that's when I just apply cold packs to them. I remember having to wear cotton gloves to sleep in and waking up in the morning and they would be nowhere to be found lol Reminds me of my husband and is gumguard. Wake up in the morning and it would be the other side of the room, under the pillow or even on my pillow waiting to greet me as I open my eyes...sounds gross but I just find it hilarious, just like the gloves that they can go walk about while we are sleeping. What the heck goes on when we are sleeping lolol