There was a thread here a while ago and we were all talking about disinfecting, etc. I had always been using alcohol, but I did some research and found that diluted bleach is the best for disinfecting. As far as disinfecting the toys, I do that with all the toys at the same time. I will only spot clean when there is a cold of something going around. I have found that when I say, "put it in the sink," then it becomes a game and I'm forever washing and putting toys back into the playroom, only to have to wash them again. IMO, kids should be exposed to regular germs. I remind them constantly not to put things in their mouths and by 2 - 2 1/2, they usually stop. On the flip side of that, I have on several occasions completely closed off the playroom for a day or two until I can disinfect everything because someone came in with a nasty bug.