There is a natural disinfectant spray that I got at All About Kids here in Ottawa..it is expensive, but I don`t use it all the time on everything. It smells kind of herbal and at least I don`t worry so much about it being toxic. I would definitely NOT be spraying with Lysol anywhere in the home (it gets into the air and we breath it), and definitely not on toys that could be put in kids`mouths. Otherwise, soap and water or sometimes bleach as it does evaporate when dry works as well. I am not convinced that disinfecting all the time actually prevents germs from ebing passed...I could wash all the toys at the end of the day, but then when the kids are here, they pass toys from kid to kid, they sneeze and cough on each other, put fingers in their noses and then touch their friends...etc. They will probably still get sick depsite your hours fo daily disinfecting...plus, as Playfelt said, they do ahve to build their immune systems up.